Epigenetic regulation in cancer chemoresistance and combined therapeutic strategies (opens in new tab)

Chemotherapy remains a cornerstone treatment for various malignancies; however, its efficacy is often limited by the development of drug resistance, which increases the risk of tumor recurrence and metastasis. Chemoresistance arises from multiple mechanisms, including enhanced drug efflux, apoptosis inhibition, increased DNA damage repair, and the maintenance of cancer stem cells (CSCs). Recent studies have revealed that epigenetic alterations play a critical role in chemoresistance. DNA meth...