Lineage tracing reveals photoreceptor precursor cell subpopulations that contribute to murine retinogenesis (opens in new tab)

IntroductionCell-based therapies hold great promise for treating late-stage retinal degenerative diseases. However, photoreceptor cell transplantation has been limited by poor cellular integration, suggesting that an ideal population of donor cells has not yet been defined.MethodsHere, we utilized single-cell RNA-sequencing and lineage tracing to assess the heterogeneity of photoreceptor precursor cells during murine retinal development.ResultsSubgroup analysis revealed three transcriptionall...