Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications (opens in new tab)

Cuproptosis is a regulated form of cell death triggered by copper overload and dependent on mitochondrial metabolism, particularly through FDX1-mediated protein lipoylation and TCA cycle disruption. Recent studies have revealed that epigenetic mechanisms, including DNA methylation, histone modifications, non-coding RNAs, and RNA chemical modifications such as m6A and lactylation, critically regulate the expression of copper transporters, lipoylation enzymes, mitochondrial metabolic proteins, ...