Computational models in directed cell migration (opens in new tab)

Directed cell migration is a fundamental biological process underlying development, tissue homeostasis, immune responses, and disease progression. While chemotaxis has long dominated conceptual frameworks of guidance, it is now clear that cells also respond robustly to physical cues such as mechanical stiffness gradients and electric fields. Still, how cells integrate multiple coexisting signals is poorly understood. Advances in experimental techniques have enabled precise control of these cu...