Organoids glimpse: the nexus for diverse tumor heterogeneity (opens in new tab)

Intratumor, intertumor and temporal heterogeneity shapes capricious therapeutic response and complicates personalized treatment. It reflects interacting genetic, epi-genetic, transcriptional, and microenvironmental variation. Patient derived organoids (PDOs) are three-dimensional, patient anchored cultures that preserve key tumor programs while enabling scalable perturbations and high dimensional readouts, making them well suited for mechanistic dissection of heterogeneity. PDO panels across ...