TRIM family proteins: dual roles in tumor immunity (opens in new tab)

Tripartite motif (TRIM) proteins represent one of the largest subfamilies of E3 ubiquitin ligases and exert complex yet critical dual roles in tumor immunology by orchestrating protein ubiquitination. This review systematically delineates the multifaceted regulatory roles of TRIM proteins in tumor immunity, with a focus on their dual functions within the tumor immune microenvironment, particularly regarding immune checkpoints and tumor-infiltrating immune cells. Notably, the same TRIM protein...