JMJD5: a multifunctional regulator in development, homeostasis, and cancer (opens in new tab)

JmjC-domain-containing oxygenases are conserved epigenetic regulators whose dysfunction is closely associated with various human diseases. JMJD5, a key member of the JmjC-Domain-Only subfamily, has multiple enzymatic activities and modulates various vital physiological and pathological processes via catalytic and non-catalytic pathways. JMJD5 also displays striking tissue-specific duality in cancer: it is frequently overexpressed and acts as an oncogene in breast, prostate, and oral squamous ...