Exploring In situ neuroprotective mechanisms of nicotine in an MPTP-Induced Parkinson’s disease rat model using spatial metabolomics (opens in new tab)

Parkinson’s disease (PD) is characterized by profound metabolic disturbances in the brain, yet how these alterations vary across brain regions and respond to neuroprotective intervention remains poorly understood. Here, we applied airflow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) to map spatial metabolic changes in whole brains from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD rats and to define the in situ metabolic effects of nicot...