Autophagy-lysosome networks in oligodendrocytes: a dynamic framework for myelin integrity (opens in new tab)

Oligodendrocytes generate and maintain myelin, a highly specialized membrane system essential for efficient signal propagation and long-term white matter integrity. The extreme biosynthetic demands and unique architecture of myelinating oligodendrocytes place exceptional pressure on intracellular quality control pathways. In this context, autophagy-lysosome networks have emerged as central regulators of oligodendrocyte biology, operating beyond bulk degradation to coordinate membrane remodeli...