Mitochondria in the middle of inter- organellar cross talk: insights from yeast to humans (opens in new tab)

Mitochondria are multifaceted organelles acting as energy, metabolic and signaling hubs in the cells. Their role as sensors, integrators and transducers of intra and extracellular inputs can drive many processes of stress response. Mitochondrial signal integration can occur at different levels involving functional and physical interactions. An example of functional interaction is the mitochondria-cytosol-nucleus cross talk, named retrograde pathway, which is evolutionary conserved from yeast ...