Advances in endogenous hypochlorous acid-mediated regulation of tumor cell fates (opens in new tab)

Hypochlorous acid (HOCl), an important reactive oxygen species generated by myeloperoxidase (MPO), is widely involved in the pathogenesis of various conditions, including cardiovascular, renal, and neurodegenerative diseases, as well as cancer. This article reviews recent progress regarding the roles of HOCl in determining cell fate and driving disease progression. We first introduce the mechanisms of HOCl formation and its explicit mechanistic links to these pathologies. Subsequently, we sum...