Targeting R-loops: diverse RNA helicases in R-loop resolution and their potential as targets for cancer therapy (opens in new tab)

RNA helicases are enzymes that remodel RNA secondary structures and RNA-protein complexes using ATP-driven motor forces. They are known to participate in many essential cellular processes, including transcription, splicing, translation, RNA decay, and ribosome assembly. However, the functional diversity of RNA helicases and the multitude of associated cofactors make it difficult to grasp the full picture of their roles in these processes. Here, we focus exclusively on the R-loop-unwinding act...