Heterogeneity-based stratification identifies CKMT2 as a prognostic marker in osteosarcoma (opens in new tab)

BackgroundOsteosarcoma (OS) is the most common primary malignant bone tumor. Intratumoral heterogeneity (ITH) contributes to therapy resistance and disease spread. Understanding the molecular structure and cellular groups contributing to ITH, as well as their clinical impacts, remains limited.MethodsTo build our investigation, we started by integrating single-cell transcriptomic data with multi-cohort transcriptomic datasets sourced from public repositories. Our bioinformatics pipeline was th...