Cell death in sepsis: unveiling new perspectives on organ dysfunction (opens in new tab)

Despite significant advances in modern intensive care, sepsis remains a life-threatening inflammatory disease worldwide. High mortality is mainly due to multiple organ dysfunction syndrome (MODS). Emerging research has shifted the focus to regulating cell death (RCD) pathways, particularly siderophosis and pyrophosphosis, which are considered major drivers of immune damage. In addition to inducing cell death, these RCD mechanisms exacerbate the inflammatory response, disrupt physiological bal...