Limitations in the clinical translation of mesenchymal stromal cells: standardisation, heterogeneity and the recipient (opens in new tab)

The therapeutic efficacy of Mesenchymal Stromal Cells (MSCs) has been demonstrated in a multitude of pre-clinical studies and clinical trials, yet the translation of MSC therapies is limited by biological factors such as inter- and intra-donor variability in the function, differentiation capacity and proliferation rate of MSCs, as well as extrinsic factors such as the implementation of standardised reporting and characterisation guidelines. The complex relationship between MSC heterogeneity a...