Adam13 interacts with large protein complexes to regulate histone modification and gene expression (opens in new tab)

Cranial neural crest (CNC) cells are a key stem cell like tissue that contribute to most of the facial structures in vertebrates. A disintegrin and metalloproteinase (ADAM) family of proteins is essential for the induction and migration of the CNC. We have shown that Adam13 interacts with the transcription factor Arid3a to regulate gene expression; we show that Adam13 modulates histone modifications in the CNC and that Arid3a binding to the tfap2α promoter is dependent on the presence of Adam...