Deciphering skeletal muscle development: cellular heterogeneity and molecular regulatory networks from single-cell and spatial transcriptomic perspectives (opens in new tab)

The development of skeletal muscle is a biological process of great complexity and high regulation whereby there is a spatiotemporal coordination of interactions amongst various cell and molecular events. Recent advances in scRNA-seq and ST have enabled systematic dissection of skeletal muscle dynamics at single-cell resolution, thereby revealing the underlying molecular regulatory processes. This review provides an overview of existing evidence on molecular components of cellular heterogenei...