Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD mice (opens in new tab)

IntroductionVisual dysfunction and retinal structural changes can occur early in Alzheimer's disease (AD), but the molecular basis of these early alterations remains unclear.MethodsWe performed quantitative proteomic profiling of the retina and brain from 4-week-old triple-transgenic AD (3xTg-AD) mice carrying human PS1M146V, APPSwe, and tauP301L mutations, prior to detectable retinal morphological abnormalities.ResultsRetinal morphology was normal in 4-week-old 3xTg-AD. Proteomic analysis id...