Tissue turnover and rejuvenation through mechanics (opens in new tab)

Tissue turnover depends on the efficient removal of damaged cells to maintain structural and functional integrity. Cells respond to damage across a spectrum of outcomes, ranging from repair and recovery to senescence, apoptosis, and malignant transformation. This review focuses on apoptosis and senescence in epithelia as two outcomes with profound consequences for tissue homeostasis, one ensuring swift mechanical removal of damaged cells and the other driving persistent tissue disruption. Whi...