Neural-immune-cancer crosstalk in pancreatic cancer: mechanisms and clinical translation (opens in new tab)

Pancreatic cancer remains a persistently high mortality rate, with limited efficacy through traditional therapies, necessitating exploration of its pathogenesis from a new biological perspective. The tumor microenvironment plays a decisive role in the malignant progression of pancreatic cancer, and the nervous system, as a key component of the microenvironment, has an active and bidirectional interaction with tumor cells, known as the “neuro-tumor interaction.” Pancreatic ductal adenocarcinom...