LRP1 in atherosclerosis: a hierarchical view of regulatory mechanisms and epigenetic knowledge gaps (opens in new tab)

Inflammation is a central driver of vascular dysfunction and plays a pivotal role in the initiation and progression of atherosclerosis. This chronic inflammatory condition arises from complex molecular, cellular, and epigenetic interactions within vascular and immune networks. Monocytes and macrophages act as key mediators of plaque development, integrating lipid handling and inflammatory signaling. Low-density lipoprotein receptor-related protein 1 (LRP1) has emerged as a multifunctional rec...