Endometrial organoid and stromal cultures demonstrate donor-derived cellular origin of the endometrium after uterus transplantation (opens in new tab)

The human endometrium undergoes cyclical regeneration during the menstrual cycle, a process thought to be driven primarily by multipotent stem cells located within the basalis layer. Previous studies have proposed that bone marrow–derived cells (BMDCs) may contribute to endometrial regeneration; however, this hypothesis remains controversial due to methodological limitations in distinguishing hematopoietic cells from resident endometrial epithelial or stromal populations. To investigate the p...