The emerging role of oncolytic virotherapy in genitourinary malignancies (opens in new tab)

Genitourinary cancers represent a significant global health burden, accounting for millions of new cases annually and high mortality, particularly in advanced disease. Conventional therapies such as surgery, chemotherapy, radiotherapy, and immune checkpoint inhibitors have improved outcomes but are often limited by resistance, tumor immune evasion, and treatment-related toxicities. Oncolytic viruses, with their dual capacity to directly lyse tumor cells and stimulate systemic anti-tumor immun...