Integrated transcriptomics identifies immune–metabolic dysregulation and candidate diagnostic biomarkers in oligoasthenozoospermia with experimental validation (opens in new tab)

ObjectiveOligoasthenozoospermia is a major cause of male infertility and is characterized by reduced sperm concentration and motility. However, candidate molecular biomarkers and integrated mechanistic frameworks for disease characterization remain limited. This study aimed to identify candidate diagnostic biomarkers for oligoasthenozoospermia and to characterize the immune–metabolic dysregulation associated with impaired spermatogenesis.MethodsThis study integrated gene expression profiles f...