Maternal microRNAs linked to birth deficits due to prenatal alcohol exposure are dominant modifiers of gene expression in invasive trophoblast cells (opens in new tab)

IntroductionPrenatal alcohol exposure (PAE) can impair placental development and result in fetal growth restriction. However, the underlying molecular mechanisms are unclear. We previously found that PAE in some, but not all pregnancies, resulted in significantly elevated circulating levels of 11 microRNAs (HEamiRNAs) in the 2nd trimester. This subgroup of PAE women experienced adverse infant birth outcomes due to PAE, Subsequently, these HEamiRNAs collectively but not individually, were foun...