LHX2: a transcription factor in development, homeostasis, repair, and disease (opens in new tab)

LIM homeobox 2 (LHX2) is a LIM-homeodomain (HD) transcription factor that participates in regulating vertebrate development, tissue homeostasis, and injury repair. This review systematically synthesizes the pleiotropic functions of LHX2 across multiple organ systems. During development, LHX2 directs regional specification and cell fate determination in the cerebral cortex, hippocampus, and retina, while regulating limb bud patterning and the development of the visual, olfactory, reproductive,...