The mechanical microenvironment and lung stem cell fate (opens in new tab)

The lung is a complex, branched organ that follows an intricate and well-coordinated developmental process to generate dozens of different cell types. Several protocols have been established to differentiate stem cells into the cell types of the lung in culture, to complement studies in animals aimed at understanding the basic processes of lung development, homeostasis, and response to injury. However, these protocols are generally both inefficient and poorly reproducible. To improve current ...