TNNT3 as a candidate node in breast cancer mechanobiology: current evidence, mechanistic models, and key knowledge gaps (opens in new tab)

Breast cancer progression is increasingly recognized as a mechanically regulated process shaped by reciprocal interactions between tumor cells and the tumor microenvironment (TME). Mechanotransduction, cytoskeletal remodeling, cell–matrix adhesion, and extracellular matrix reorganization all contribute to tumor growth, invasion, and metastatic dissemination. TnT3, traditionally known as a component of the troponin (Tn) complex involved in striated muscle contraction, has recently attracted at...