Relationships between immune cells, blood metabolites, and intrahepatic cholangiocarcinoma: a Mendelian randomization study with experimental validation (opens in new tab)

IntroductionIncreasing studies have found links between immune traits and intrahepatic cholangiocarcinoma (ICC). However, the presence of confounding variables makes it difficult to determine if this correlation shows a real cause-and-effect relationship.MethodsTo ascertain the genetic association between immune cell profiles and the risk of ICC, we employed two-sample Mendelian randomization (MR) to figure out the potential therapeutic targets. A mediation analysis was performed to identify ...