Hair follicle organoids: advances in construction, applications, and translational challenges (opens in new tab)

Hair follicles (HFs) are complex mini-organs characterized by a highly organized structure and cyclic regeneration. In recent years, hair follicle organoids (HFOs) have emerged as promising three-dimensional in vitro models that partially recapitulate the architecture and function of native hair follicles, providing new opportunities for studying hair biology and related disorders. This review first outlines the key biological features of HFs and highlights the essential role of epithelial–me...