Assessment of Vedolizumab and UC-MSC interaction and therapeutic potential in acute graft-versus-host-disease (opens in new tab)

Acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation, characterized by donor T-cell-mediated immune responses against the host. This condition significantly impacts patient quality of life, and it is associated with mortality, particularly when the gastrointestinal tract is affected. This study investigated the potential therapeutic synergy between umbilical cord-derived mesenchymal stromal cells (UC-MSCs), known for ...