Integrating multi-omics and reverse network toxicology to identify pollutant risks and potential intervention targets in pulmonary arterial hypertension (opens in new tab)

BackgroundIdiopathic pulmonary arterial hypertension (PAH) is a progressive cardiovascular disorder with high mortality. Although both genetic and environmental factors are implicated in its pathogenesis, the underlying mechanisms remain unclear.MethodsWe integrated transcriptomic data from PAH lung tissue, GWAS summary statistics, and QTL data for DNA methylation, gene expression, and plasma protein. Core dysregulated genes were first identified via differential expression and protein-protei...