Context-dependent miRNA regulation in intervertebral disc degeneration: an IDD-focused dynamic network framework for stage-specific therapeutics (opens in new tab)

Intervertebral disc degeneration (IDD) is a progressive, mechanically regulated, and inflammation-associated disease in which microRNAs (miRNAs) participate in extracellular matrix remodeling, cell death, inflammatory signaling, and intercellular communication. However, the reported functions of individual miRNAs in IDD are often inconsistent across studies, with the same miRNA being associated with protective, neutral, or pro-degenerative outcomes under different experimental or pathological...