Traditional Chinese medicine-derived monomers improve bone metabolic imbalance and delay osteoporosis progression by regulating mitochondrial homeostasis (opens in new tab)

Osteoporosis is a systemic metabolic bone disease characterized by reduced bone mass, microarchitectural deterioration, and increased fracture risk. Its pathogenesis is driven by an imbalance between insufficient osteoblast-mediated bone formation and excessive osteoclast-mediated bone resorption. In recent years, mitochondrial homeostasis has emerged as an important pathological hub in this process. Beyond energy production, mitochondria regulate redox balance, mitophagy, apoptosis, senescen...