GDI2 protein: research progress and its mechanisms in diseases (opens in new tab)

GDP dissociation inhibitor 2 (GDI2), also termed RabGDIβ, is an evolutionarily conserved Rab GDP dissociation inhibitor that is broadly expressed across species and is required for fundamental cellular functions. Mechanistically, GDI2 controls the cycling of Rab small GTPases between membranes and the cytosol, thereby regulating Rab-dependent membrane targeting, intracellular trafficking, and downstream signal transduction. Increasing evidence indicates that GDI2 is not only a constitutive co...