Evidence of Sertoli cell lineage contribution to the rete testis population during embryonic development (opens in new tab)

The rete testis (RT) develops at the gonad-mesonephros interface and links seminiferous tubules to efferent ductules, but the cellular origins of RT cells and the mechanisms driving RT expansion during embryonic development remain incompletely resolved. Here, to test whether gonadal Sertoli cell (SC) lineage cells contribute to the developing RT, we applied a chimeric organotypic culture approach combining gonadal and mesonephric compartments of GFP+ and GFP-mouse embryonic urogenital complex...