Novel insights of ferroptosis in atherosclerosis progression (opens in new tab)

Atherosclerosis (AS) is the principal pathological basis of multiple cardiovascular and cerebrovascular diseases and remains a major cause of morbidity and mortality worldwide. Accumulating evidence indicates that ferroptosis, a form of iron-dependent regulated cell death driven by lipid peroxidation, is intricately involved in the initiation and progression of AS. Aberrant iron accumulation, redox imbalance, and impaired antioxidant defenses contribute to endothelial dysfunction, macrophage ...