Lysophosphatidylethanolamine (LysoPE) in health and disease: a narrative review of its pathophysiological mechanisms and translational potential as a biomarker (opens in new tab)

Lysophosphatidylethanolamine (LysoPE) is a key class of lysophospholipid molecules that play important roles in regulating cell membrane structure, signal transduction, and metabolic regulation. This review consolidates current knowledge on LysoPE’s molecular mechanisms, including its biosynthesis, membrane dynamics, and signaling via GPCRs, MAPK, and PI3K/AKT pathways. We critically analyze its context-dependent roles across major disease categories. In metabolic diseases, abnormal LysoPE le...