Cisplatin resistance in ovarian cancer: exploration and insights from metal ion homeostasis imbalance (opens in new tab)

Ovarian cancer remains a lethal gynecological malignancy, and cisplatin resistance is a major therapeutic barrier. Beyond classical mechanisms, dysregulated redox homeostasis is now recognized as a key determinant of cellular fate and chemoresistance. Metabolic reprogramming in cancer cells critically perturbs the cellular redox system, positioning mitochondria—a nexus of metabolism and redox signaling—as a promising therapeutic target for modulating platinum sensitivity. Importantly, metabol...