Dialysis vintage modifies the effect of adsorption-based therapies on protein-bound toxin clearance (opens in new tab)

IntroductionThe efficiency of hemodialysis varies substantially across different solute classes, but the determinants of this variability remain poorly characterized, limiting personalized prescription.MethodsIn this prospective randomized study, 60 maintenance hemodialysis patients were assigned to three modalities: hemodiafiltration (HDF), hemodialysis with HA130 hemoperfusion, and hemodialysis with KHA130 hemoperfusion. Clearance of p-cresyl sulfate (PCS), β2-microglobulin (β2-MG), advance...