Tubulin monoglutamylation is sufficient to rescue the ciliary motility defects in a Chlamydomonas polyglutamylation deficient mutant (opens in new tab)

IntroductionThe axonemes of eukaryotic cilia and flagella display high tubulin glutamylation heterogeneity, yet the functional significance of this variation remains elusive. We previously showed that long-chain polyglutamylation is crucial for ciliary motility in Chlamydomonas. However, the respective contributions of long-chain polyglutamylation versus short-chain species to motility remain unclear, as existing mutants did not allow for a clear functional dissection of these two modificatio...