Mitochondria-targeted strategies in cancer radiotherapy: from ROS regulation to immunogenic cell death (opens in new tab)

Radiotherapy (RT) is a crucial treatment modality for various solid tumors. Its antitumor effects not only depend on direct DNA damage but also involve the disruption of redox homeostasis centered around mitochondria and the activation of immune responses. Mitochondria, as a central hub for cellular energy metabolism and apoptosis signaling, serve both as the primary source of reactive oxygen species (ROS) and as key targets for ROS attack during RT. RT promotes the sustained accumulation of ...