FGFR inhibitor resistance in cervical cancer: a role for integrin α2 and mTOR signalling (opens in new tab)

Cervical cancer is the fourth most common cancer among women worldwide and is often diagnosed at advanced stages, highlighting the need for effective systemic therapies, including those targeting key cancer-related pathways. Fibroblast growth factor (FGF) signalling plays a critical role in cell biology, activating FGF receptors (FGFRs) to regulate proliferation, migration and apoptosis. Aberrant activation of the pathway contributes to tumour progression in many cancers, including cervical c...