DEHP induces stress urinary incontinence by causing urethral sphincter dysfunction via inflammation and apoptosis: a mechanism study based on animal experiments... (opens in new tab)

ObjectiveDi (2-ethylhexyl) phthalate (DEHP), a pervasive environmental pollutant, poses significant health risks, yet its role in stress urinary incontinence (SUI) remains largely unexplored.MethodsThis study integrated network toxicology, molecular docking, and animal experiments to investigate DEHP-induced SUI mechanisms.ResultsThrough cross-analysis of multiple public databases, we identified 95 potential targets linking DEHP exposure to SUI. GO and KEGG enrichment analyses revealed that t...