H2S-mediated protein S-sulfhydration: a novel regulatory module in lipid metabolism (opens in new tab)

H2S-mediated protein S-sulfhydration is an emerging post-translational modification that regulates key biological processes via regulating enzyme activities, controlling protein–protein interactions, and modulating signal transduction. Lipid metabolism represents an important target of S-sulfhydration–mediated regulation, which fine-tunes lipid metabolic networks including fatty acid turnover, triglyceride metabolism, and cholesterol homeostasis. This review aims to systematically summarize c...