Fibrinogen in extracellular matrix remodeling: functional switching, source heterogeneity, and biomaterial translation (opens in new tab)

Fibrinogen (FG), which is typically regarded as a circulating coagulation protein, is now supported by growing evidence as also serving as a context-dependent regulator of extracellular matrix (ECM) remodeling during tissue repair, inflammation, fibrosis, cancer progression, and biomaterial-mediated regeneration. In this review, we examine how FG activity is shaped by local concentration, polymerization state, proteolytic processing, post-translational modification, receptor availability, mat...