CRISPR-based next-generation molecular diagnostics for bone infection (opens in new tab)

Bone and joint infections, notably osteomyelitis and periprosthetic joint infections, present a profound clinical challenge characterized by severe morbidity, prolonged hospitalizations, and substantial healthcare costs. Effective management is persistently hindered by diagnostic uncertainty. Conventional microbiological cultures yield false-negative results in up to 50% of cases, largely due to prior antibiotic exposure, biofilm formation, and fastidious organisms. Concurrently, the escalati...