Understanding multi-azole resistance in Aspergillus fumigatus: the impact of non-cyp51A mutation and efflux pump overexpression (opens in new tab)

IntroductionAzole resistance in Aspergillus fumigatus is an emerging global concern, significantly limiting treatment options for aspergillosis. The present study aimed to investigate azole resistance mechanisms, focusing on non-cyp51A mutations and efflux pump genes overexpression in environmental isolates of A. fumigatus.MethodsA total of 156 soil samples collected from 13 states across India were screened for azole-resistant A. fumigatus isolates. Antifungal susceptibility testing was perf...