Clinical Talaromyces marneffei isolates exhibit enhanced stress tolerance and diminished antifungal responsiveness relative to non-clinical strains (opens in new tab)

IntroductionTalaromycosis, caused by the dimorphic fungus Talaromyces marneffei, is a significant opportunistic infection in HIV/AIDS patients in Southeast Asia. This study aimed to investigate the antifungal susceptibility of clinical T. marneffei strains (from HIV-positive and HIV-negative patients) and non-clinical strains, and to compare their adaptability to various stress conditions.MethodsA total of 196 T. marneffei strains were assessed using broth microdilution and Sensititre YeastOn...