Dietary restriction as a potential neuroprotective intervention: a narrative review of its impact on neuroinflammation across neurodegenerative diseases and other neurological disorders (opens in new tab)

Dietary restriction (DR) involving chronic or intermittent calorie/nutrient reduction without malnutrition, delays neurological disease progression. Decades of research across in vitro models, animal studies, and clinical trials provide preclinical evidence for a potential role of DR in modulating multiple mechanisms underlying CNS disorders. Interactions between caloric intake, meal frequency, diet composition, and the gut microbiome regulate specific metabolic pathways governing cellular, t...